The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Therapeutics Development Initiative, 2010Selective Inhibition of Cyclic Nucleotide Phosphodiesterase Type 7 (PDE7): A Novel and Efficacious Approach to Treating Parkinson's Disease
Promising Outcomes of Original Grant:
We are investigating a regulatory enzyme (type-7 cyclic nucleotide phosphodiesterase, PDE7) as a novel therapeutic target for the treatment of Parkinson’s disease... -
MJFF Research Grant, 2010Regulated rAAV-GDNF to treat Parkinson's disease: Translational research plan
Objective/Rationale:
We are attempting to perfect gene therapy using glial cell line-derived neurotrophic factor (GDNF) for Parkinson’s disease. One part of developing this gene therapy is... -
Rapid Response Innovation Awards, 2011Identifying Approved and Investigational Drugs with Activity on Parkinson's Disease Targets
Objective:
Our objective is to identify known, safe drugs that are useful for treating Parkinson’s disease (PD). Most drugs work by interacting with specific molecular ‘targets’ in the human body, such... -
Rapid Response Innovation Awards, 2011Activation of GPR88 by a Small Molecular Weight Compound: Screening for Drug-like Modulators of GPR88 Function
Objective/Rationale:
The expression pattern of GPR88 within the brain suggests a role for this receptor in the control of motor function. The natural binding partner for GPR88 is not known. However... -
MJFF Research Grant, 2011Characterization of Inflammatory Mediators During Early Stages of Parkinson's Disease
Objective/Rationale:
Inflammatory activation has been a widely observed feature in the substantia nigra of Parkinson’s disease (PD) patients, and inflammatory stimuli can cause selective nigral cell... -
Target Validation, 2011TFEB and Its Associated MicroRNA-128 as Targets for Neuroprotection and Disease Intervention in Parkinson´s Disease
Objective/Rationale:
Recent studies indicate that degenerative changes seen in Parkinson´s disease (PD) may be linked to impairments in the cells´ ability to degrade toxic proteins, such as misfolded...
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Our funding programs support basic, translational and clinical research from academia and industry.