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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Accelerating Biological Understanding and Therapeutic Translation for Parkinson’s Disease Program, 2022
    Advancing Biological Understanding of PINK1 and Parkin Rodent Models of Parkinson’s Disease

    Study Rationale: Although loss-of-function mutations in the PINK1 and Parkin genes are known to cause early onset Parkinson’s disease (PD), the cellular and molecular mechanisms remain uncertain. We...

  • Translational Pipeline Program, 2022
    Prevention of Dementia in GBA-associated Parkinson’s Disease

    Study Rationale: Whereas motor symptoms can be well controlled by dopamine-enhancing drugs and deep brain stimulation, dementia represents a key milestone in the course of Parkinson’s disease (PD)...

  • Research Grant, 2022
    Establishing a Parkinson’s Disease Registry in West Virginia

    Study Rationale: The state of West Virginia has one of the nation’s highest rates of Parkinson’s disease (PD), a condition for which the causes are not well understood and there is no cure. In April...

  • Translational Pipeline Program, 2022
    Development of a Nurr1 Activator as a Novel Therapeutic for Parkinson’s Disease

    Study Rationale: Nurr1 is a protein that works in the nucleus of dopamine-producing nerve cells in the brain to keep these cells functioning normally. Emerging evidence suggests that impaired function...

  • Research Grant, 2022
    Longitudinal Endpoint Optimization to Provide an Assessment of Relevant Drugs in Parkinson’s Disease (LEOPARD-PD)

    Study Rationale: The Parkinson’s Disease-Health Index (PD-HI) is a novel, disease specific patient-reported outcome (PRO) measure designed for use in clinical trials to track clinically meaningful...

  • Parkinson’s Pathway Molecular Data Analysis Program, 2022
    Assessment of Proinflammatory Cytokines as Biomarkers for Parkinson’s Disease

    Study Rationale: We have generated a computer-based model that simulates alterations in molecular mechanisms associated with Parkinson’s disease (PD) genes. This model suggested that, in sporadic...

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