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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Research Grant, 2022
    Development of a Safe and Efficient Method to Treat Parkinson’s Disease Using RNA-based Gene Therapy

    Study Rationale: Gene mutations are one of several cause of Parkinson’s disease (PD). Developing an efficient method for introducing functional versions of these mutated genes into cells that are...

  • Research Grant, 2022
    Identifying Bothersome Symptoms, Impacts of Disease and Relevance of WATCH-PD Digital Measures Over Time in Early Parkinson’s Disease

    Study Rationale: Parkinson’s disease (PD) is a devastating neurologic disease and current treatments are unable to prevent the worsening of symptoms. One problem in developing new therapies has been...

  • Research Grant, 2022
    Interaction of Mitochondrial Genes and Lifestyle Factors on Age at Onset in Parkinson’s Disease

    Study Rationale: Cellular structures called mitochondria are functionally impaired in Parkinson’s disease (PD). How environmental toxins or lifestyle factors influence mitochondrial function and...

  • Therapeutic Pipeline Program, 2022
    Evaluating the Efficacy of a mGluR5 Modulator in Preclinical Models of Parkinson’s Disease

    Study Rationale: Parkinson’s disease (PD) is one of many neurodegenerative diseases that are characterized by the buildup of misfolded protein aggregates in the brain. Preclinical data suggest that...

  • Spring 2022 RFA: Target Advancement Program - Target Validation, 2022
    Examining the Action of Potassium Channels and the Inflammasome in a Signaling Axis That Can Serve as a Pharmacological Target Against Parkinson’s Disease

    Study Rationale: Both voltage-gated potassium channels and inflammatory signaling are known to be involved in Parkinson’s disease (PD). Each of these signaling systems contributes to the brain...

  • Expanding Biological Understanding of PD, 2022
    Identifying Genes that Enhance the Activity of Glucocerebrosidase

    Study Rationale: Parkinson’s disease (PD) causes uncontrollable trembling, progressive rigidity of muscles and an inability to walk. We do not yet understand why certain people are more prone than...

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