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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Research Grant Supplement, 2012
    Generation and Characterization of iPS Neurons from Genetic Parkinson’s Disease

     

    Promising Outcomes of Original Grant:
    The goal of the previous project was to establish iPS-derived neurons from patients with PINK1- and Parkin-linked familial forms of PD.  We used the latest...

  • Clinical Intervention Awards, 2012
    A Randomized Controlled Trial of Neurocognitive and Supportive Therapy Interventions for Individuals with Parkinson’s Disease
    Objective/Rationale: In the twenty-first century the motor symptoms of Parkinson’s disease (PD) are typically well-managed. The neurocognitive symptoms of Parkinson’s disease often result in...
  • Therapeutics Development Initiative, 2012
    Lead Optimization for a Parkinson's Disease Therapeutic

    Objective/Rationale: 
    CuII(atsm) has the potential to delay disease progression in Parkinson’s disease, based on extensive pre-clinical model data. CuII(atsm) has been shown to significantly improve...

  • Target Validation, 2012
    DLN-101 for the Treatment of Parkinson’s Disease
    Objective/Rationale: Dln101 is a novel protein from the ghrelin family. Dln101 has several clinical and commercial advantages over ghrelin, which make it a more attractive drug target. In previous...
  • Novel Approaches to Drug Discovery, 2012
    Optimizing Metalloporphryins for Clinical Development Supplement 2

    Promising Outcomes of Original Grant:
    A newly developed glyoxylate series of metalloporphyrin compounds designed to penetrate the blood brain barrier have shown high potencies as antioxidants. A recent...

  • Repositioning Drugs for PD, 2012
    Improving Levodopa Bioavailability and Consistency of Absorption through Co-administration of GSK962040

    Objective/Rationale:
    Parkinson’s disease (PD) often results in slower than normal emptying of food and medications from the stomach. This delayed gastric emptying is estimated to affect 50-90 percent...

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