The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Target Validation, 20145-alpha-reductase Inhibition for the Treatment of Levodopa-induced Dyskinesia
Study Rationale:
Although the cause of levodopa-induced dyskinesia is still unclear, these motor complications appear to be due to abnormal dopamine transmission in the brain. Compelling evidence has... -
Research Grant, 2014Evaluation of mGlu4 Positive Allosteric Modulators in Models of Parkinson’s Disease
Study Rationale:
Levodopa and other available treatments for Parkinson’s disease (PD) are initially effective but have unpredictable therapeutic effects and induce serious adverse... -
Therapeutic Pipeline Program, 2014Liver X Receptor Agonists as Novel Therapeutics for Parkinson’s Disease
Study Rationale:
Inflammation is an early and characteristic feature of Parkinson’s disease. Recent studies connect a protein called the liver X receptor (LXR) to inflammation in key... -
Cognition Biomarkers, 2014miRNA Markers of Cognition
Objective/Rationale:
In previous MJFF-funded research, these researchers identified four promising microRNAs (which regulate gene expression) associated with cognitive status. They profiled the miRNAs... -
Cognition Biomarkers, 2013Validation of Novel and Traditional Quantitative EEG Biomarkers
Objective/Rationale:
Cognitive problems commonly add to the disability of the motor symptoms of Parkinson’s disease (PD), but there are no highly effective treatments for cognitive dysfunction in PD... -
LRRK2 Challenge, 2013Physiological Role of Lysosomal LRRK2 in the Regulation of CMA
Objective/Rationale:
Brain cells rely on very efficient surveillance systems to identify defective components and break them apart to avoid accumulation and toxicity. Research has shown that in the...
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Our funding programs support basic, translational and clinical research from academia and industry.