The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Clinical Intervention Awards, 2012Phase I Study of AAV2-hAADC Administered by MRI-guided Real-time Convective Infusion
Objective/Rationale:
The purpose of this study is to provide safety data related to enhancements in the clinical delivery procedure for administering Adeno-Associated Virus Encoding Human Aromatic L... -
Repositioning Drugs for PD, 2012Amitriptyline as a Dopamine Neuroprotective Therapy
Objective/Rationale:
The project proposes to repurpose the tricyclic antidepressant medication, amitriptyline (AMI), as a disease-modifying therapy for Parkinson’s disease (PD). AMI is an FDA-approved... -
Neurotrophic Factors Challenge, 2012Validation of IGF-1 as a Neuroprotective Agent in Pre-clinical Models of Parkinson’s DiseaseObjective/Rationale: IGF-1-mediated intracellular signaling pathways engage a wide range of potential survival mechanisms, the PI3K/Akt pathway and the ER stress response in particular, and it has...
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MJFF Research Grant, 2012Analysis of Archived Tissue from Parkin, DJ-1, PINK1 and LRRK2 KO Pre-Clinical Models
Objective/Rationale:
As part of a broad effort to develop preclinical models of Parkinson’s disease (PD), MJFF sponsored the generation and initial characterization of knockout pre...
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MJFF Research Grant, 2012Novel PD Tools: Generation of Posttranslationally Modified Alpha-synuclein
Objective/Rationale:
There is increasing evidence linking specific posttranslational modification (folding, cutting, etc. of proteins before maturation) and alpha-synuclein aggregation... -
Target Validation, 2012Validating Monoacylglycerol Lipase Inhibitors in Combatting Parkinson’s Disease
Objective/Rationale:
Chronic and persistent inflammation in the brain has been shown to be an underlying driver of Parkinson’s disease (PD). Anti-inflammatory strategies may be beneficial...
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Our funding programs support basic, translational and clinical research from academia and industry.