The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Summer 2022 RFP: Expanding Biological Understanding of Parkinson's Disease, 2022Assessing Whether Cholesterol or Its Metabolites Increase the Risk of Developing Parkinson’s Disease
Study Rationale: Parkinson’s disease (PD) has been associated with a dysregulation of cholesterol metabolism in brain cells and the accumulation of a protein called alpha-synuclein. Our research is...
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Research Grant, 2022Performing a First-In-Human Study of a Retinal Tracer For Alpha-synuclein in Parkinson's Disease
Study Rationale: Like the brain, the retina is part of the central nervous system. We therefore aim to develop a new and simple way to diagnose Parkinson’s disease (PD) via examination of the eye. To...
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Summer 2022 RFP: Accelerating the Translation of Parkinson's Disease Therapies, 2022Developing an Inhibitor of Transglutaminase 2 as a Disease-modifying Treatment for Parkinson’s Disease
Study Rationale: Clumping of alpha-synuclein in the brain is a key pathological feature of Parkinson’s disease (PD) and is believed to lead to brain cell degeneration. Identifying factors that...
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Spring 2022 RFA: Target Advancement Program - Target Validation, 2022Evaluating an Insulin-degrading Enzyme as a Novel Therapeutic Target for Parkinson’s Disease
Study Rationale: In Parkinson’s disease (PD), the clumping of the protein alpha-synuclein in the brain causes the death of neurons. Recent studies have shown that the insulin-degrading enzyme (IDE)...
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Summer 2022 RFP: Accelerating the Translation of Parkinson's Disease Therapies, 2022Validation of a Novel Mitochondrial Drug Target for Parkinson’s Disease
Study Rationale: Mitochondria provide cells with energy, but they also help regulate the flow of large amounts of calcium ions that flood neurons when they are active. In Parkinson’s disease (PD)...
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Research Grant, 2022Development of a Safe and Efficient Method to Treat Parkinson’s Disease Using RNA-based Gene Therapy
Study Rationale: Gene mutations are one of several cause of Parkinson’s disease (PD). Developing an efficient method for introducing functional versions of these mutated genes into cells that are...
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Our funding programs support basic, translational and clinical research from academia and industry.