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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • MJFF Research Grant, 2012
    Targeting the Unfolded Protein Response (UPR) Transcription Factor XBP1 to Alleviate Neurodegeneration Triggered by Alpha-synuclein

    Objective/Rationale: 
    Our general aim is to investigate the role of a specific component of a cellular stress response, known as the Unfolded Protein Response, in the development of Parkinson's disease...

  • MJFF Research Grant, 2012
    Mechanisms of Cellular Regulation and Post-translational Modification of LRRK2

    Promising Outcomes of Original Grant:
    We have identified methods to increase or decrease the ratio of cytosolic LRRK2 compared to membrane-localized LRRK2 as well as methods to increase or decrease the...

  • Research Grant, 2012
    Phase I-B Clinical Trial of AVE8112 for Cognitive Impairment in Parkinson’s Disease

    Objective/Rationale:
    Cognitive impairment is a symptom seen in Parkinson’s disease (PD) patients, and some can progress to dementia. AVE8112 is a PDE4 inhibitor that was in development by the...

  • Target Validation, 2012
    Targeting the JAK/STAT Pathway in the Treatment of Parkinson's Disease

    Objective/Rationale: 
    Parkinson’s disease (PD) involves inappropriate activation of the immune system.  Cytokines activate immune cells by engaging the JAK/STAT pathway, which receives signals from...

  • MJFF Research Grant, 2012
    The Role of Amyloid in the Progression of Cognitive Impairment in PD: A Prospective Cohort Study

    Objective/Rationale:             
    Dementia is a frequent and devastating non-motor complication of Parkinson's disease (PD). Although loss of dopamine producing brain cells play a role in cognitive...

  • Target Validation, 2012
    Evaluation of the Microtubule-Stabilizing Agent, Epothilone D, in Mouse Models of Parkinson's Disease

    Objective/Rationale:             
    Microtubules are critical components within nerve cells, where they serve as the “railroad” tracks upon which cellular cargo is transported up and down the length of...

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Our funding programs support basic, translational and clinical research from academia and industry.

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