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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Alpha-synuclein Biology Challenge, 2012
    Alpha-synuclein Aggregation Leads to Loss of Functional Forms of the Protein and Toxicity

    Objective/Rationale:
    The protein alpha-synuclein has been linked to Parkinson’s disease (PD). The prevailing hypotheses state that this protein is directly toxic to neurons and thus the removal of...

  • LRRK2 Challenge, 2012
    Characterizing Region Specific Splice Isoforms of LRRK2

    Objective/Rationale:             
    LRRK2 is one of the most important genetic risk factors that we know about for Parkinson’s disease: Tens of thousands of people in the US have mutations in this gene...

  • Resource: Utilizing DATATOP Biospecimens, 2012
    Protein S-Nitrosylation as a Potential Biomarker for Parkinson’s Disease

    Objective/Rationale:             
    Oxidative and nitrosatvie stress, related to reactive nitrogen (N) and oxygen (O) species, can cause protein misfolding, aggregation and dysfunction, and thus...

  • Dyskinesia Challenge, 2012
    AVP-923 for Levodopa-induced Dyskinesia in Parkinson's Disease

    Objective/Rationale:
    Dextromethorphan regulates glutamate and serotonin, brain chemicals that help control movements. In people with Parkinson's disease (PD), brain chemical alterations, coupled with...

  • Rapid Response Innovation Awards, 2012
    Glycosylated Opioid Peptides For the Treatment of Levodopa-Induced Dyskinesias

    Objective/Rationale:
    Nearly all Parkinson's patients will eventually be treated with levodopa. However, the majority of patients will eventually develop disabling side effects known as levodopa-induced...

  • Alpha-synuclein Biology Challenge, 2012
    Normal Role of Synuclein in Mitochondrial Bioenergetics at the Synapse

    Objective/Rationale:
    Decreasing levels of a-synuclein (SYN) is a promising therapeutic strategy for PD, but the safety of lowering SYN has not been established. Although the normal functions of SYN are...

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