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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Target Validation, 2012
    Cannabinoid CB2 Receptors as a New Target for the Treatment of Disease Progression in Parkinson's Disease: Studies in LRRK2-Transgenic Pre-clinical Models

    Objective/Rationale:             
    Cannabinoids provide neuroprotection in neurodegenerative disorders through the activation of specific targets within the so-called endocannabinoid system. The case...

  • Resource: Utilizing DATATOP Biospecimens, 2012
    Circulating MicroRNAs: a New Paradigm for Parkinson's Disease Biomarker Discovery

    Objective/Rationale:             
    We aim to assess miRNA stability and evaluate the potential of previously identified PD-predictive circulating miRNAs as progression biomarkers for PD using MJFF...

  • MJFF Research Grant, 2012
    Pre-clinical Safety Study of LRRK2 Inhibitors

    Objective/Rationale:             

    LRRK2 is well recognized as a potential central nervous system target for the treatment of Parkinson’s disease (PD).  For development as possible therapeutic drugs...

  • Resource: Utilizing DATATOP Biospecimens, 2012
    Small-molecule PD Biomarkers: a Metabolomic Analysis

    Objective/Rationale:             
    Based on our earlier findings that yielded several promising biomarkers, this metabolomic study of small-molecule biochemicals will investigate specimens from...

  • Dyskinesia LEAPS, 2012
    Xenon Inhalation to Reduce L-DOPA-Induced Dyskinesia

    Levodopa is the most effective drug to treat symptoms of Parkinson’s disease, however long-term use leads to disabling L-DOPA-induced dyskinesia (LID) in the vast majority of patients. NMDA receptor...

  • MJFF Research Grant, 2012
    Intrinsic Remodeling of the Fovea in Parkinson’s Disease

    Promising Outcomes of Original Grant:
    In the past we determined the part of the retina (the back of the eye) which needs to be measured for PD induced changes. We developed an equation which permits...

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