The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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MJFF Research Grant, 2009Neoangiogenesis and blood-brain barrier in L-DOPA-induced dyskinesia
Promising Outcomes of Original Grant:
Working on a pre-clinical model of Parkinson´s disease, we have found that levodopa treatment induces proliferation of endothelial cells and angiogenesis in the... -
MJFF Research Grant, 2009Specific Inhibition of Nucleation of Alpha-Synuclein Aggregation as a Therapeutic Strategy
The discovery of specific genes associated with rare, genetic forms of Parkinson’s disease has opened the opportunity to investigate the mechanisms of the disease and to develop novel drugs. Parkinson...
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Understanding LRRK2 Biology, 2009Building a LRRK2 Cohort Core Database
Objective/Rationale:
MJFF is funding the expansion of two international LRRK2 cohorts to gain insight into the relationship of this genetic mutation to Parkinson’s disease. Within each funded study... -
MJFF Research Grant, 2009A Pre-clinical Alpha-Synuclein Model of Parkinson's Disease
Objective/Rationale:
This project will aim to establish the behavioral and neuroanatomical correlates of injecting a viral vector that overexpresses the gene for alpha-synuclein into the brains of non... -
Clinicopathological Correlations of Parkinson’s Disease, 2009Evaluation of the Enteric Nervous System in PD
Objective/Rationale:
Gastrointestinal (GI) symptoms (constipation, for example) afflict essentially every PD patient, negatively impact quality of life, and diminish effectiveness of oral medications... -
Clinicopathological Correlations of Parkinson’s Disease, 2009Metabolomic Analysis of Parkinson's Disease Cerebrospinal Fluid
Objective/Rationale:
Metabolomic analysis is a state-of-the-art laboratory technique and computerized analysis used to catalog hundreds of the chemical constituents in the brain environment. We will...
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Our funding programs support basic, translational and clinical research from academia and industry.