The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Therapeutics Development Initiative, 2009Determination and Validation of the Molecular Target of J3, a Neuroprotective Lead Compound, for Its Optimization as a Disease-modifying Candidate for Parkinson's Disease
Objective/Rationale:
We have identified a small molecule, designated J3, which shows promising neuroprotection in an acute animal model of Parkinson’s disease (PD). To reach our ultimate goal of... -
Biomarkers, 2009Analysis of the Enteric Nervous System Using Routine Colonic Biopsies: A Biomarker of Neurodegeneration in Parkinson's Disease
Objective/Rationale:
The “core” of the neuronal lesions of Parkinson’s disease (PD) is the progressive degeneration of dopamine neurons in the central nervous system (CNS). It is now well established... -
Biomarkers, 2009Development of an mGluR5 Imaging Marker for Parkinson's Disease
Objective/Rationale:
The goal of this proposal is to develop an imaging test, 18F-PEB PET, to assess glutamate function in the brain of individuals with Parkinson disease (PD) and determine if the... -
Biomarkers, 2009High Resolution Diffusion Tensor MRI Imaging as a Biomarker of Parkinson's Disease Diagnosis and Disease Progression
Objective/Rationale:
As Parkinson’s disease (PD) is moving into the era of neuroprotective interventions one of the major objectives is the development of a biomarker of PD diagnosis. This study... -
Biomarkers, 2009Development of an alpha6*-Selective Neuronal Nicotinic Receptor (NNR) Imaging Agent as a Parkinson's Disease Biomarker
Objective/Rationale:
The availability of a selective PET radiotracer for the drug target is critical for determining receptor occupancy in humans. NNR subtypes containing the alpha? subunit have been... -
Biomarkers, 2009High Resolution Diffusion Tensor Imaging in Parkinson's Disease and Parkinson Plus Syndromes
Objective/Rationale:
An objective and valid trait and state biomarker of Parkinson’s disease will help therapeutic development by providing a measure to help confirm diagnosis (trait), and track...
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Our funding programs support basic, translational and clinical research from academia and industry.