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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Research Grant, 2010
    LRRK2 Effects on Neural Differentiation

    Objective/Rationale
    Several lines of research suggest that leucine-rich repeat kinase 2 (LRRK2 or PARK8) levels or its activity can regulate the development of axons or dendrites, but some of the...

  • MJFF Research Grant, 2010
    Determine the Structure of LRRK2 Protein

    Objective/Rationale
    Mutations in the Leucine Rich Repeat Kinase 2 (LRRK2) gene are associated with Parkinson’s disease (PD).  Although the biological function of LRRK2 is not known, inhibitors of...

  • MJFF Research Grant, 2010
    Role of mGluR4 in the Modulation of Levodopa-induced Motor Performance and Dyskinesia

    Objective/Rationale
    Dyskinesias are uncontrollable involuntary body movements that constitute a major clinical problem associated with the long term treatment of Parkinson’s disease (PD) using...

  • MJFF Research Grant, 2010
    Developing Circuit-Targeting Optogenetic Strategies for Pre-Clinical Model Motor Circuitry

    Objective/Rationale
    Optogenetics is a new technology that allows control of brain cells with light- in a way that allows targeting of control to well-defined subsets of cells in vivo, even if those...

  • MJFF Research Grant, 2010
    Regulation of LRRK2 Membrane Association

    Objective/Rationale
    Mutations in LRRK2 are the most common genetic cause of Parkinson’s disease. The LRRK2 gene encodes a large multi-domain protein with kinase activity. LRRK2 protein is normally...

  • MJFF Research Grant, 2010
    Multi-tracer positron emission tomography (PET) functional imaging as a tool to assess the relevance of rodent LRRK2 models to the human neurochemical phenotype associated with LRRK2 mutations related Parkinsonism

    Objective/Rationale
    Transgenic pre-clinical models are instrumental to investigate mutation-induced abnormalities at the bio-chemical, cellular level in a manner not possible in humans. In humans...

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Our funding programs support basic, translational and clinical research from academia and industry.

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