The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Expanding Biological Understanding of PD, 2021Assessing Inhibition of NLRP3 to Reduce Brain Inflammation in Parkinson’s Disease
Study Rationale:
Recent studies indicate that brain inflammation caused by activation of a protein complex called the NLRP3 inflammasome worsens Parkinson’s disease (PD). Although multiple drugs that... -
Analysis of Patient-Reported Outcomes from Fox Insight, 2021Characterizing Impairment Trajectories in People with Parkinson’s Disease
Study Rationale:
Little is known about what causes individuals with Parkinson’s disease (PD) to develop symptoms, much less the genetic and non-genetic factors that influence these changes. In most... -
Analysis of Patient-Reported Outcomes from Fox Insight, 2021Exploring Environmental and Genetic Mediators of Progression in Parkinson’s Disease
Study Rationale:
We currently do not understand why some people with Parkinson’s disease (PD) have particularly severe symptoms, or symptoms that progress rapidly, compared to those who do not. This... -
Target Advancement Program, 2021Developing a Protein Quality Control Mechanism as a Novel Therapy for Parkinson’s Disease
Study Rationale:
Parkinson’s disease is a disorder of protein misfolding and aggregation. It is characterized by the presence of Lewy bodies and Lewy neurites: aberrant intracellular structures... -
Analysis of Patient-Reported Outcomes from Fox Insight, 2021Using Risk Scores to Link Molecular Mechanisms to Clinical Outcomes in Parkinson's Disease
Study Rationale:
The symptoms and course of Parkinson’s disease (PD) show remarkable variation from one person to another, indicating differences in the underlying disease process that may also be... -
Therapeutic Pipeline Program, 2021Compounds that Enhance the Activity of GCase as a Treatment for Parkinson’s Disease
Study Rationale:
Beta-glucocerebrosidase (GCase), a protein that processes some of the key components of cell membranes, is required for normal brain function. Reduced activity of this protein...
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Our funding programs support basic, translational and clinical research from academia and industry.