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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Resource: Utilizing Samples from the Arizona Parkinson’s Di, 2012
    Preferential Loss of Serotonin Axon Subtypes in Depression in Parkinson's Disease

    Objective/Rationale:
    Depression occurs in Parkinson’s disease (PD) much more frequently than in the general population, and is a major factor contributing to decreased quality of life for affected...

  • MJFF Research Grant, 2012
    Network Biomarkers for the Assessment of Parkinson's Disease: A Multi-modal Optimization Study

    Objective/Rationale:
    This study will compare positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) for measuring the activity of Parkinson's disease-specific brain...

  • Rapid Response Innovation Awards, 2012
    Development of an HTS Assay to Break the Alpha-Synuclein-Glucocerebrosidase Feedback Loop

    Objective/Rationale:             
    We aim to develop a novel screening platform to identify candidate drugs to treat Parkinson’s disease.  The screening platform incorporates the link between alpha...

  • LRRK2 in the Immune System, 2012
    Does Peripheral Immune Challenge Exacerbate LRRK2-Induced Neuronal Pathology?

    Objective/Rationale:             
    Neuro-immune interactions may have etiological roles in the development of several neurodegenerative disorders. LRRK2 is a cell signaling protein and when mutated, is...

  • LRRK2 in the Immune System, 2012
    Clinical Evaluation of LRRK2 Inhibitors on Inflammatory Responses in Crohn's and Parkinson's Diseases

    Objective/Rationale:             
    Leucine-rich repeat kinase 2 (LRRK2) is genetically associated with several human diseases, including Parkinson’s disease (PD) and Crohn’s disease (CD). Recent...

  • Dyskinesia Challenge, 2012
    Combined Therapy with Amantadine and Fenobam for Levodopa-induced Dyskinesia

    Objective/Rationale:
    Amantadine is currently the only available medication to treat levodopa-induced dyskinesia: involuntary, jerky movements caused by long-term use of the Parkinson’s drug levodopa...

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