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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Rapid Response Innovation Awards, 2012
    A Small Molecule Approach to Correct Striatal Cholinergic Interneuron Dysfunction

    Objective/Rationale:
    There is growing evidence that cholinergic interneurons (ChIs) in the striatum undergo maladaptive biochemical changes leading to their hyperactivation under conditions of...

  • LRRK2 Biology LEAPS, 2012
    Protein Interaction Network Analysis and Pathway Modeling for LRRK2

    Objective/Rationale:
    Mutations in the Leucine-rich Repeat Kinase 2 gene (LRRK2) are the single most common cause for inherited Parkinson's disease (PD). LRRK2 is a large protein consisting of...

  • MJFF Research Grant, 2012
    Neuroimaging Markers Predict Cognitive Decline in PD

    Promising Outcomes of Original Grant:
    Excessive amounts of amyloid in brain tissue are believed to be toxic and cause the neuronal damage that results in dementia.  Amyloid deposits can be detected in...

  • MJFF Research Grant, 2012
    Mechanisms of Parkin Recruitment and Mitophagy

    Promising Outcomes of Original Grant:
    The protein Parkin is thought to be required for the maintenance of healthy mitochondria, critical subcellular organelles that govern cellular energy production...

  • Rapid Response Innovation Awards, 2012
    Mifunctional Cembranoids for Therapy of Parkinson’s Disease

    Objective/Rationale:
    Although considerable achievements have been made in the understanding of pathophysiology of Parkinson’s disease (PD), there are still limited effective approaches available for...

  • Dyskinesia Challenge, 2012
    The Effects of Memantine on Levodopa Induced Dyskinesias (LIDs) in MPTP-treated Pre-clinical Models

    Objective/Rationale:
    Levodopa is the mainstay of treatment for the motor symptoms of Parkinson’s disease.  Unfortunately one of the long term side effects of levodopa treatment is the development of...

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Our funding programs support basic, translational and clinical research from academia and industry.

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