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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Antibody Comparison, 2011
    Characterization of LRRK2 Monoclonal Antibodies in Pre-clinical Brain Tissue

    Objective/Rationale: 
    Mutations in Leucine Rich Repeat Kinase 2 (LRRK2) are implicated in Parkinson’s disease in humans. At present we understand neither the normal nor the pathogenic role of LRRK2. We...

  • Rapid Response Innovation Awards, 2011
    Salivary Gland Biopsies as a Diagnostic Test for Parkinson's Disease

    Objective/Rationale: 
    We have previously found that in autopsied patients with Parkinson’s disease the hallmark finding in the brain (Lewy body or Lewy neurite) is also found in the submandibular gland...

  • Rapid Response Innovation Awards, 2011
    Inflammatory Insults in Early Life and Susceptibility to Parkinson's Disease in Later Life

    Objective/Rationale: 
    Researchers have reported that early-life inflammation in the brain may increase a risk for development of Parkinson’s disease (PD), but the mechanisms involved remain unclear. ...

  • Rapid Response Innovation Awards, 2011
    Identifying Approved and Investigational Drugs with Activity on Parkinson's Disease Targets

    Objective:
    Our objective is to identify known, safe drugs that are useful for treating Parkinson’s disease (PD). Most drugs work by interacting with specific molecular ‘targets’ in the human body, such...

  • Rapid Response Innovation Awards, 2011
    Activation of GPR88 by a Small Molecular Weight Compound: Screening for Drug-like Modulators of GPR88 Function

    Objective/Rationale: 
    The expression pattern of GPR88 within the brain suggests a role for this receptor in the control of motor function.  The natural binding partner for GPR88 is not known. However...

  • MJFF Research Grant, 2011
    Characterization of Inflammatory Mediators During Early Stages of Parkinson's Disease

    Objective/Rationale: 
    Inflammatory activation has been a widely observed feature in the substantia nigra of Parkinson’s disease (PD) patients, and inflammatory stimuli can cause selective nigral cell...

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