The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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LRRK2 Role in Idiopathic Parkinson's Disease, 2014Use of Lrrk2-associated Cellular Fingerprints to Link Familial Forms to Idiopathic Forms of Parkinson’s Disease
Objective/Rationale:
Clinical and genetic findings have established a clear link between the LRRR2 gene and Parkinson’s disease. To what extent and by what mechanisms LRRK2 contributes to... -
LRRK2 Challenge, 2013Investigating the Role of LRRK2 in Mycobacterial Infection
Objective/Rationale:
Mutations in the LRRK2 gene are the most common known genetic risk factors for Parkinson's disease. Although we know that these mutations can cause Parkinson's disease... -
LRRK2 Cohort Consortium Resource Request, 2013Alpha-synuclein and Other Biomarkers in Biological Samples of LRRK2 Parkinson’s Disease
Objective/Rationale:
Cerebrospinal fluid (CSF) biomarkers of Alzheimer’s pathology have been investigated in Parkinson’s disease (PD), and abnormal CSF protein levels (tau and phosphorylated tau, beta... -
Dyskinesia Challenge, 2013NOP Receptor Agonists for Preventing Levodopa-induced Dyskinesia
Objective/Rationale:
Dyskinesia (involuntary fractured, jerky movements) is a debilitating side effect of long-term levodopa treatment for Parkinson’s motor symptoms. Previous studies have... -
Research Grant, 2014Direct Reprogramming of Functional, Induced Dopaminergic Neurons from Human Adult Somatic Cells
Promising Outcomes of Original Grant:
We have established a new procedure to directly convert skin fibroblasts (a type of cell) from pre-clinical models into induced dopaminergic (iDA) neurons. We have... -
Cognition Biomarkers, 2013Alpha-synuclein and Cognitive Decline in Parkinson’s Disease
Objective/Rationale:
Variability in the SNCA gene (which encodes alpha-synuclein, the protein that clumps in Parkinson’s disease) is a major risk factor for PD. Using next-generation...
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Our funding programs support basic, translational and clinical research from academia and industry.