The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Target Advancement Program, 2016Role of LRRK2 in GCase-mediated Alterations in Lysosome Function and Alpha-synuclein Metabolism
Study Rationale:
Mutations in the lysosomal (enzyme storage unit) enzyme GCase are associated with an increased risk of Parkinson's disease (PD) and cause alpha-synuclein (protein associated with... -
Improved Biomarkers and Clinical Outcome Measures, 2016Brainstem and Olfactory System Biomarkers of Early Parkinson's Disease
Study Rationale:
There is a great need to identify Parkinson's disease (PD) in its earliest stages when interventions may prevent or slow neural degeneration. Given that the earliest brain pathology... -
Target Advancement Program, 2016GADD34 Inhibition as a Neuroprotective Strategy in Parkinson's Disease
The lack of disease-modifying therapies is a crucial deficiency in the treatment of Parkinson disease (PD). Using cellular models of PD, we have identified the protein GADD34 as a novel potential...
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Therapeutic Pipeline Program, 2018Exosomal Delivery of shRNA Minicircles to Halt Neurodegeneration and Parkinson's
Study Rationale:
Gene therapy is one of the most promising tools for the treatment of Parkinson's disease (PD). We have developed a novel system to treat brain diseases using exosomes, which are small... -
Target Advancement Program, 2018Role of Neuromelanin in Parkinson's Disease and Brain Aging
Study Rationale:
In Parkinson's disease (PD), there is a selective degeneration of brain cells that contain the dark-brown pigment neuromelanin, especially dopamine-producing cells in part of the... -
Target Advancement Program, 2018Engineering Protective Immune Cells for the Treatment of Parkinson's Disease
Study Rationale:
Toxic proteins produced in the brains of people with Parkinson's disease (PD) are known to set off an immune response. In the course of this response, inflammatory lymphocytes --...
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Our funding programs support basic, translational and clinical research from academia and industry.