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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Target Validation, 2011
    Overexpression of CSPalpha Using Viral Vectors in the Striatum of a-Syn 1-120 Transgenic Pre-clinicalModel

    Objective/Rationale:
    Research data have recently indicated that pathology in Parkinson’s disease (PD) starts at the synapse, the part of the neurons where release of dopamine occurs, dysfunction of...

  • Rapid Response Innovation Awards, 2011
    Role of Striatal-Enriched Protein Tyrosine Phosphatase 61 (STEP61) in Parkinson's Disease

    Objective/Rationale:
    The Park2 gene product parkin is implicated in both genetic and sporadic forms of Parkinson’s disease (PD). Defective parkin function leads to the accumulation of toxic proteins...

  • Target Validation, 2011
    Pre-clinical Models Specifying Nicotinic Receptor Targets in Parkinson's Disease Neuroprotection

    Objective/Rationale:
    The scientific community has known since 1959 that tobacco use has apparent protective effects against Parkinson’s disease (PD), and some animal models suggest that this...

  • Dyskinesia, 2011
    Targeting Serotonin Transporters for the Treatment of L-DOPA-induced Dyskinesia

    Objective/Rationale:
    Levodopa remains the gold-standard treatment for Parkinson’s disease, unfortunately chronic treatment leads to abnormal involuntary movements known as dyskinesia. In recent years...

  • Biomarkers, 2011
    Identifying Peripheral Inflammatory Markers for Parkinson's Disease with Dementia (PDD)

    Objective/Rationale:
    Patients with Parkinson’s disease (PD) are at a 5.9 times greater risk of developing dementia than the normal population. The identification of sensitive molecular and cellular...

  • Rapid Response Innovation Awards, 2011
    Effect of Deep Brain Stimulation on Cortical Cross Frequency Coupling in Parkinson's Disease: An Electrocorticography Study

    Objective/Rationale:
    Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a common treatment for Parkinson’s disease (PD). Much research has focused on the effects of DBS on the STN and...

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