The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Therapeutic Pipeline Program, 2016Effect of HDAC Inhibition in Models of Parkinson's Disease
Study Rationale:
Numerous publications have linked the family of epigenetic enzymes known as HDACs (histone deactylases) to the underlying pathology of Parkinson's. This study will test the efficacy of... -
Therapeutic Pipeline Program, 2016Cognitive Behavioral Therapy for Anxiety Disorders in Parkinson's Disease
Study Rationale:
Anxiety disorders occur in up to 35 percent of people with Parkinson's disease and can have a negative impact on gait, involuntary movements, motor fluctuations and quality of life... -
Therapeutic Pipeline Program, 2016Rehabilitation Treatment for Airway Protection in Parkinson's Disease
Study Rationale:
Aspiration pneumonia is a leading cause of death in persons with Parkinson's disease (PD). One of the main reasons people with PD develop aspiration pneumonia is that they often have... -
Research Grant, 2016GBA Meta-analysis Initiative: Charting a Path to Success for Clinical Trials in Patients with GBA-PD
Promising Outcomes of Original Grant:
We ascertained the associations between GBA mutations and cognitive and motor outcomes in seven large cohorts representing 2,304 patients with PD (including 221... -
Therapeutic Pipeline Program, 2016Blocking Inflammasome-induced Neuroinflammation in Parkinson's Disease with a Potent, Orally Available Small Molecule
Study Rationale:
Our brains are full of immune cells called microglia, which fight infections and clear the brain of toxic products. In Parkinson's disease, these cells are constantly active, leading... -
Target Advancement Program, 2016Pharmacological Targeting of Proinflammatory Kinase Signaling in Parkinson's Disease
Study Rationale:
In Parkinson's disease, the brain's resident immune cells, called microglia, can become persistently activated due to the accumulation of alpha-synuclein-containing protein clumps...
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Our funding programs support basic, translational and clinical research from academia and industry.