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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Therapeutic Pipeline Program, 2013
    Development of Trehalose as a Disease-modifying Treatment for Parkinson’s Disease

    Objective/Rationale:             
    The development of Parkinson’s disease (PD) is linked to the accumulation of the toxic protein alpha-synuclein. Systems within neurons able to clear alpha-synuclein...

  • Biosample and Tissue Resource, 2013
    From Genetic Risk Toward Genetic Prognosis

    Objective/Rationale: 
    The progression and prognosis of Parkinson’s disease (PD) varies considerably between individual patients — ranging from a manageable, functional decline to an aggressive course...

  • Research Grant, 2013
    Development of Highly Sensitive Immunoassays for pS129 Alpha-synuclein in Human Samples

    Objective/Rationale:             
    The development of disease-modifying therapies in Parkinson’s disease requires the availability of quantitative biomarkers for use in primary diagnosis, monitoring...

  • LRRK2 Pharmacodynamic Assays, 2013
    Measuring LRRK2 Phosphorylation by Flow Cytometry

    Objective/Rationale:             
    There is a possibility that inhibitors of the leucine-rich repeat kinase 2 (LRRK2) protein could be used for treating Parkinson’s disease. Our projects aims to develop...

  • LRRK2 Cohort Consortium Resource Request, 2013
    Penetrance of LRRK2 in the LRRK2 Cohort Consortium

    Objective/Rationale:             
    Estimates for development of Parkinson’s disease (PD) and age of onset in carriers of LRRK2 G2019S mutations vary widely (24 to 100% by age 80). Factors including...

  • LRRK2 Pharmacodynamic Assays, 2013
    Development of a Sensitive Assay to Correlate LRRK2 Kinase Activity and Conformational State

    Objective/Rationale:             
    A major function of LRRK2, a protein kinase, is the modification of other proteins through a process known as phosphorylation. It appears that the kinase activity of...

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