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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Rapid Response Innovation Awards, 2013
    Control of the Nigrostriatal Pathway by the Tail of the Ventral Tegmental Area

    Objective/Rationale:
    Neuroanatomical inputs to the substantia nigra pars compacta (SNc) modulate the activity of dopamine neurons and could influence the symptoms of Parkinson’s disease. A new brain...

  • Biosample and Tissue Resource, 2013
    Assessing Glucocerebrosidase in Sporadic Parkinson’s Disease

    Objective/Rationale:             
    Mutations in the glucocerebrosidase (GBA) gene are the most common genetic risk factor for Parkinson’s disease (PD). These mutations are present in approximately seven...

  • Research Grant, 2013
    Exosome/Microvesicle Release from LRRK2 Mutant iPSC-derived Neural Cells

    Objective/Rationale:             
    Exosomes/microvesicles are small vesicles that are shed from the cell membrane and are known to play a role in communication between cells. Exosomes/microvesicles...

  • Research Grant, 2013
    Evaluation of Alpha-synuclein Immunohistochemical Methods for the Detection of Lewy-type Synucleinopathy in Gastrointestinal Biopsies

    Objective/Rationale:             
    Lewy bodies, which consist mainly of aggregated protein alpha-synuclein, are a pathological hallmark of Parkinson’s disease (PD). Lewy bodies in the enteric nerves...

  • Biosample and Tissue Resource, 2013
    Measuring LRRK2 Levels and Activity in Sporadic Parkinson’s Disease

    Objective/Rationale:             
    Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been linked to Parkinson’s disease (PD). The most prevalent mutation, G2019S, results in increased...

  • Parkin Biology, 2013
    Identification of De-ubiquitinating Enzymes for Parkin-mediated Mitophagy

    Objective/Rationale:             
    There is an urgent need to understand the cell processes that contribute to the cause of Parkinson’s disease. Parkin is an active enzyme within the cell that provides...

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