The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Parkinson’s Disease Therapeutics Pipeline Program, 2024Use of the Dual-action Neuroprotective Compound KLS-13019 to Treat Motor Impairment in a Preclinical Model of Parkinson’s Disease
Study Rationale: Parkinson’s disease (PD) is associated with a loss of mitochondrial function and increased inflammation. A dual-action drug candidate, KLS-13019, both protects mitochondria from...
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Research Grant, 2024Developing a Binding Assay to Detect Toxic Alpha-synuclein Aggregates in Cerebrospinal Fluid and Plasma
Study Rationale: The formation of toxic protein aggregates is an early step in the pathology of several neurodegenerative disorders, including Parkinson’s disease (PD). Using computer simulations, we...
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Parkinson’s Disease Therapeutics Pipeline Program, 2024Preclinical Development of a Novel Therapeutic for Parkinson’s Disease
Study Rationale: Inflammation in the brain (neuroinflammation) is a key feature of Parkinson’s disease (PD), and signaling molecules called prostaglandins play a pivotal role in controlling chronic...
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Research Grant, 2024(SUPPLEMENT) Cataloguing Proteomic Differences in LRRK2-Associated Parkinsonism With and Without Evidence of Pathologic Neuronal Alpha-synuclein
Study Rationale: Alpha-synuclein is a protein found throughout the brain and body. In most people with Parkinson’s disease (PD), an accumulation of abnormal alpha-synuclein is thought to contribute to...
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Biomarkers to Support Therapeutic Trials Program, 2024Using Detection of Apoptosing Retinal Cells to Predict Disease Activity in Parkinson’s Disease
Study Rationale: In preclinical models, detection of apoptosing retinal cells (DARC) allows identification of cells in the eye that are under stress and at risk of damage from Parkinson’s disease (PD)...
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Research Grant, 2024Developing A Resource for Exploring the Molecular Markers of Parkinson’s Disease
Study Rationale: Our understanding of the genetic, immunological and molecular determinants of Parkinson’s disease (PD) has advanced significantly over the past decade. Using this extensive body of...
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Our funding programs support basic, translational and clinical research from academia and industry.