The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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GBA Biology and Therapies, 2018Link between LRRK2 Activity and Glucocerebrosidase Deficits in Idiopathic Parkinson’s Disease
Study Rationale:
Earlier work from this group reported greater LRRK2 activity in people with idiopathic (cause unknown) Parkinson’s. This project builds on those findings to investigate how that... -
GBA Biology and Therapies, 2019Resolving the Pathophysiology of Parkinson's Disease with GBA Mutations
Study Rationale:
Mutations in the GBA gene are the greatest genetic risk factor for developing Parkinson’s disease (PD). We will systematically examine pathophysiological pathways in PD patients with... -
GBA Biology and Therapies, 2018Analyzing Genetic Modifiers Using a CRISPR Activation/Inhibition GBA-PD Model
Study Rationale:
Clinical and genetic studies show that mutations in the GBA gene are risk factors for developing Parkinson’s disease (PD) and lead to an accumulation of glycolipids in the lysosome... -
GBA Biology and Therapies, 2018Targeting GCase with Novel Pharmacological Chaperones
Study Rationale:
People who have mutations in the GBA gene have a higher chance of developing Parkinson's disease (PD). The GBA gene encodes the glucerebrosidase (GCase) protein, an enzyme located... -
GBA Biology and Therapies, 2018Impact of Genetic Variants in GBA on Parkinson’s Disease
Study Rationale:
Changes to the DNA sequence are risk factors for Parkinson’s disease. While we know where many of these changes occur in our DNA, we still do not know how they cause Parkinson’s... -
GBA Biology and Therapies, 2019Identification of Targets of Neurotoxic Sphingolipids Using iPSCs from People with GBA-associated Parkinson’s Disease
Study Rationale:
GBA encodes the enzyme beta-glucocerebrosidase (GCase), which is required to maintain function of the cell’s lysosomes, which break down unnecessary cellular parts. Mutations in GBA...
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Our funding programs support basic, translational and clinical research from academia and industry.