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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Parkin Therapeutic Development, 2013
    Identification of Parkin Activators through Structure-Function Analyses

    Objective/Rationale:             
    Mutations in the Parkin gene are the most common cause of recessive familial Parkinson’s disease. Additionally, the Parkin protein may also be inactivated in...

  • Rapid Response Innovation Awards, 2013
    Determination of the 3D Structure of Biologically Active Small Molecules in Complex with DJ-1

    Objective/Rationale:             
    Mutations in the DJ-1 gene have been associated with Parkinson’s disease onset. This project will determine the 3D structure of the DJ-1 protein in complex with novel...

  • Target Validation, 2013
    Targeting the Voltage-Gated Proton Channel Hv1 for Neuroprotection

    Objective/Rationale:             
    The goal of this project is to validate the voltage-gated proton channel Hv1 as a target to reduce neuroinflammation and subsequent neurodegeneration in acute and...

  • Target Validation, 2013
    Bach1 and Bach2 Inhibit Nrf2 Antioxidant Responses in Substantia Nigra Neurons

    Objective/Rationale:             
    Oxidative stress and damage are well-known contributors in the pathogenesis of Parkinson’s disease (PD). To combat oxidative damage, transcription factor Nrf2...

  • Research Grant, 2013
    LRRK2 Effects on Neural Differentiation (Supplement 2)

    Promising Outcomes of Original Grant:
    Mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) account for up to 13% of familial Parkinson's disease (PD) patients, but the function of LRRK2...

  • LRRK2 Challenge, 2013
    Impact of LRRK2 Kinase Activity on Synaptic Vesicle Trafficking 2013

    Objective/Rationale:
    Synapses provide a connection that allows signals to travel between neurons. Pre-clinical research showed that the LRRK2 kinase may influence synaptic function through effects on...

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