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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Specification, Patterning, and Maintenance of Midbrain Dopam, 2004
    Identification of Novel Determinants for Dopamine Neuron Generation in Vivo and in Embryonic Stem Cells

    Understanding how the different cells of the brain are generated during embryonic development is one of the fundamental questions in biology. Recent studies have elucidated several key mechanisms...

  • MJFF Research Grant, 2004
    Simple Blood Tests for Parkinson's Disease Derived from Genome-wide Expression Changes

    In work from their initial grant, Drs. Steven Gullans and Clemens Scherzer at Brigham and Women’s Hospital identified a number of genes that are differentially expressed in blood cells of patients...

  • MJFF Research Grant, 2002
    Characterization of Alpha Synuclein in Human Fluids & Brain as a Biomarker for Parkinson's Disease

    Dr. Michael Schlossmacher and his colleagues at Brigham and Women's Hospital are looking at levels of the protein alpha-synyclein in the blood as a possible biomarker for PD. Mutations in alpha...

  • Cell Line, 2006
    Improving the Long-term Survival & Functionality of the Transplanted Human Dopaminergic Neurons Through Space Creation Strategy

    Dr. Xuejun Wen was awarded a one-year award in 2004 as part of the MJFF Cell Line II program. Dr. Wen proposed to test a novel biodegradable ‘spacer’ device to improve embryonic stem (ES) cell-derived...

  • Molecular Mechanisms of Dyskinesia in Parkinson's Disease, 2005
    Mechanisms of Graft-Induced Dyskinesias in an Animal Model of Parkinson's Disease (Supplemental Funding)

    Our ongoing project has four aims:

    1. To develop a model of graft-induced dyskinesia (GID) in the rat, which will provide a cost-effective tool for studying the mechanisms of this complication;
    2. To...
  • Rapid Response Innovation Awards, 2007
    Gene-Environment Interactions in Parkinson's Disease

    Objective/Rationale:
    Although the causes of sporadic Parkinson’s disease are still unknown, recent evidence suggests that exposure to pesticides increases the risk for PD. However, most of these...

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