Funded Studies

Study Rationale: Studies have shown that a regulatory factor called REST could promote the survival of neurons in neurodegenerative conditions. This factor is produced in greater quantities with age...

Study Rationale: Parkinson’s disease (PD) has long been associated with mitochondrial dysfunction. Perturbation of these subcellular structures can lead to the release of reactive oxygen species (ROS)...

Study Rationale: Inhibitors of the LRRK2 protein offer promise as a therapy for Parkinson’s disease (PD). The leading inhibitors currently under development, the so-called Type 1 kinase inhibitors...

Study Rationale: To evaluate treatments in ways that are meaningful to people with Parkinson’s disease (PD), we need to identify measurements that reflect how people with early PD function and feel...

Study Rationale: Mutations in the genes encoding PRKN and PINK1 are associated with Parkinson’s disease (PD). PINK1 and PPKN proteins work together to mediate the degradation of damaged mitochondria...

Study Rationale: The clinical phase of Parkinson’s disease (PD) is preceded by a prodromal phase of progressing neurodegeneration that can last many years. Imaging markers such as radiolabeled AV-133...