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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Research Grant, 2022
    Shoring Up a Medical Chemistry Approach to Treating Parkinson’s Disease: The Bridge Initiative

    Study Rationale: The proteins parkin and GCase show a strong genetic link to Parkinson’s disease (PD) and are key players of biological pathways often disrupted in the disorder. This connection makes...

  • Proof-of-Concept Testing of PD Therapeutics, 2022
    Using Data from the LEAPS Project to Improve the Accuracy of Assays that Measure Alpha-synuclein

    Study Rationale: The scientific and clinical research community working on Parkinson’s disease (PD) is in need of biomarkers to facilitate the monitoring of disease progression and efficacy of...

  • Target Advancement Program, 2022
    Enhancing N-glycosylation of Glucocerebrosidase and other Lysosomal Enzymes as a Disease Modifying Therapy for Parkinson’s Disease

    Study Rationale: Parkinson’s disease (PD) is an age-related neurological movement disorder characterized by the abnormal aggregation of a protein called α-synuclein (α-syn) in the brain. Normally...

  • Spring 2022 RFP: Proof-of-Concept Testing of PD Therapeutics, 2022
    Identification and Quantification of Parkinson’s Disease Progression Using Digital Measures from a Wrist-worn Wearable Device - a Retrospective Study

    Study Rationale: The combination of digital measures and machine learning (ML) holds great promise for improving critical aspects of Parkinson’s disease (PD) care, practice and research. Earlier PD...

  • Spring 2022 RFA: Target Advancement Program - Target Validation, 2022
    Validating BMPs as Novel Drug Candidates for Parkinson’s Disease

    Study Rationale: Neurotrophic factors are prime candidates for the development of disease-modifying therapies, based on their properties to restore and maintain the functional integrity of neurons...

  • Spring 2022 RFP: Proof-of-Concept Testing of PD Therapeutics, 2022
    Project Title: Clinical Development of PDM608, a Potential Neuroprotective and Anti-inflammatory Long-acting Biologic for Parkinson’s Disease

    Study Rationale: Targeting neuroinflammation by increasing T regulatory cell numbers is a promising strategy for treating Parkinson’s disease. We propose a Phase 1 trial in non-PD volunteers for our...

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