The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Biomarkers, 2021Measurement of Mitochondrial DNA in Early Stages of Parkinson’s Disease
Study Rationale:
People with a form of idiopathic REM sleep behavior disorder (iRBD) experience nightmares and lash out physically during a stage of sleep when the body's muscles are normally... -
Therapeutic Pipeline Program, 2021Novel Inhibitors of Protein Aggregation as Potential Therapeutics for Parkinson’s Disease
Study Rationale:
The protein alpha-synuclein can aggregate in brain cells, which leads to brain cell death in Parkinson’s disease (PD). We plan to investigate a novel class of drugs — called protein... -
Therapeutic Pipeline Program, 2021Pharmacological Targeting of Inflammation to Modify Disease Progression in Pre-clinical Models of Parkinson’s Disease
Study Rationale:
Parkinson’s disease (PD) is a progressive neurodegenerative disease characterized by pronounced brain inflammation. Despite being the most common movement disorder to date, no therapy... -
Therapeutic Pipeline Program, 2021Development of Compounds that Destroy Alpha-Synuclein Aggregates for the Treatment of Parkinson’s Disease
Study Rationale:
Multiple lines of evidence indicate that alpha-synuclein forms aggregates similar to those adopted by infectious prion proteins, and that these toxic clusters are responsible for the... -
Biomarkers, 2021Use of Neuronal Exosomes to Predict Parkinson’s Disease
Study Rationale:
In Parkinson’s disease (PD), the build-up of alpha-synuclein inside nerve cells leads to formation of abnormal clumps and death of dopamine-producing cells and other neurons. By the... -
Environmental Risk Factors, 2021Exposure to Ambient Air Pollution and Risk of Parkinson’s Disease
Study Rationale:
Ambient (outdoor) air pollution can increase the risk of cardiovascular diseases and death. Some evidence links ambient air pollution to higher risk of Parkinson’s disease. But...
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Our funding programs support basic, translational and clinical research from academia and industry.