The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Access to Data and Biospecimens, 2017LRRK2 in predicting Parkinson disease risk and progression in LRRK2 mutation carriers
Study Rationale:
The G2019S mutation in the LRRK2 gene is responsible for thousands Parkinson disease (PD) cases. But, not all of the mutation carriers will develop PD. Currently, clinicians...
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LRRK2 Biology Consortium, 2017Identification of Network, Activity and Behavioral Signatures of LRRK2 Expression
Promising Outcomes of Original Grant:
Our original project investigated how the LRRK2 mutation, the principal genetic cause of Parkinson's disease (PD), alters brain activity involved in movement... -
Research Grant, 2016Investigation of the Role of PINK1-dependent Phosphorylation of Rab GTPases in Parkinson’s Disease
Study Rationale:
Mutations in the PINK1 gene lead to Parkinson’s disease. PINK1 belongs to a special class of enzymes known as protein kinases. We recently found that PINK1 targets a family of enzymes... -
Priority Target Award, 2016Advancing PINK1 Knockout Models of Parkinson’s
Study Rationale:
Loss-of-function mutations in PINK1 are causally linked to early-onset Parkinson’s disease (PD). MJFF funded the generation and initial characterization of PINK1 knockout (KO) models... -
Therapeutic Pipeline Program, 2016KH176 as a Novel Disease-modifying Therapeutic for Parkinson’s Disease
Study Rationale:
Mitochondrial dysfunction has a prominent role in the process of Parkinson’s disease (PD). Mutations in at least seven genes are known to underlie PD, most of them encode proteins that... -
Therapeutic Pipeline Program, 2016Long-term Cell Restorative Treatment for Parkinson’s Disease
Study Rationale:
Cell replacement therapies for Parkinson’s disease (PD) propose to replace the lost dopaminergic neurons in the brain. Transplanted fetal dopamine neurons have...
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Our funding programs support basic, translational and clinical research from academia and industry.