The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Improved Biomarkers and Clinical Outcome Measures, 2016Brainstem and Olfactory System Biomarkers of Early Parkinson's Disease
Study Rationale:
There is a great need to identify Parkinson's disease (PD) in its earliest stages when interventions may prevent or slow neural degeneration. Given that the earliest brain pathology... -
Target Advancement Program, 2016GADD34 Inhibition as a Neuroprotective Strategy in Parkinson's Disease
The lack of disease-modifying therapies is a crucial deficiency in the treatment of Parkinson disease (PD). Using cellular models of PD, we have identified the protein GADD34 as a novel potential...
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Research Grant, 2016Combining Mass Spectrometry with Genetic and Pharmacological Approaches to Discover and Validate LRRK2 Substrates
Study Rationale:
The kinase (protein regulator) LRRK2 is thought to play an important role in both familial (inherited) and sporadic (no known cause) Parkinson's disease (PD). Unfortunately, a lack of... -
Target Advancement Program, 2016Targeting RER1 in Models of Parkinson's Disease
Study Rationale:
Abnormal build-up of the protein alpha-synuclein in Parkinson's disease (PD) has been linked to cell stress and death. These deficits can be rescued by expressing certain proteins... -
Target Advancement Program, 2016Alpha-synuclein Toxicity in LRRK2 Pre-clinical Models and Rescue by LRRK2 Silencing
Study Rationale:
Genetic mutations that alter the function of the LRRK2 protein increase the risk of developing a form of Parkinson's disease (PD). Age and other environmental factors combine with... -
Biomarkers Across Neurodegenerative Diseases, 2016Seeds of Dementia: Misfolded Proteins in Neurodegenerative Disorders
Study Rationale:
Alzheimer's disease (AD), Lewy Body Dementia (LBD) and frontotemporal dementia (FTD) are characterized by the accumulation of specific proteins in the brain. The identification of...
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Our funding programs support basic, translational and clinical research from academia and industry.