The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Access to Data and Biospecimens, 2015Lysosomal Enzyme Activity and GBA1 Genotyping in Parkinson’s Disease
Study Rationale:
The dysfunction of the systems responsible for the clearance of the protein alpha-synuclein plays a major role in Parkinson’s disease (PD). The lysosome is an... -
Therapeutic Pipeline Program, 2015Utilization of Aptamers to Prevent Protein Aggregation in Parkinson’s Disease
Objective/Rationale:
The abnormal aggregation of a protein known as alpha-synuclein appears to play a critical role in Parkinson's disease. This project will explore a new type of... -
Improved Biomarkers and Clinical Outcome Measures, 2015Developing Progression Markers of Parkinson’s Disease with Multimodal Structural MRI of Substantia Nigra and Locus Coeruleus
Study Rationale:
Substantia nigra pars compacta (SNpc) and locus coeruleus (LC) are key brain areas involved in Parkinson’s disease. The loss of important chemicals (dopamine and norepinephrine) made... -
Research Grant Supplement, 2015Identification of the Parkin-binding Domain for SLP-2 as a Potential Therapeutic Target Supplement
Promising Outcomes of Original Grant:
The objective of our Rapid Response Innovation Awards-supported project was to identify the parkin domain that interacts with Stomatin-like protein 2 (SLP-2), a... -
Research Grant, 2015Nuclear Magnetic Resonance Analysis to Support Development of Alpha-Synuclein Imaging Agents
Study Rationale:
The Michael J. Fox Foundation Imaging Consortium has identified several promising compounds that bind specifically to alpha-synuclein fibrils, the clumps of protein that accumulate in... -
Target Validation, 2015Transcription Factors as Key Targets to Regulate The Selective Vulnerability of Dopamine Neurons
Study Rationale:
Why specific subsets of brain cells such as those containing the chemical messenger dopamine are particularly vulnerable and degenerate is one of the central...
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Our funding programs support basic, translational and clinical research from academia and industry.