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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • MJFF Research Grant, 2010
    LRRK2 G2019S Disease Penetrance Modifiers

    Objective/Rationale: 
    The most commonly found mutation in Parkinson’s disease patients is LRRK2 G2019S.  This mutation can lead to the development of Parkinson’s disease at very different ages, from...

  • MJFF Research Grant, 2010
    Characterization of an Inhibitor Compound of LRRK2 Function

    Objective/Rationale: 
    LRRK2 (Leucine-Rich Repeat Kinase 2) is a protein thought to be involved in regulating signaling pathways in cells. Mutations in the gene for LRRK2 are associated with some...

  • Research Grant, 2010
    Symptoms and Side Effects of LRRK2 Mutation Carriers and Assessment of Factors Influencing LRRK2-related PD Expression

    Objective/Rationale: 
    By incorporating our Spanish LRRK2 cohort with G2019S and R1441G mutations into the existing LRRK2 Cohort Consortium (L2CC) of people of Ashkenazi Jewish and North African Arab...

  • MJFF Research Grant, 2010
    Development of Selective LRRK2 Inhibitors

    Objective/Rationale:
    LRRK2 kinase has been implicated as a potential therapeutic target for the treatment of Parkinson’s disease. The goal of our project is to make experimental drugs to test whether...

  • Therapeutics Development Initiative, 2010
    Development of a Zinc Finger Protein Therapeutic for the Potential Treatment of Parkinson's Disease

    Objective/Rationale:
    Engineered zinc finger protein transcription factors (ZFP TFs) can be designed to specifically increase the level of a therapeutically important protein from its native gene in a...

  • Biomarkers, 2010
    Optimizing Biochemical Biomarkers for PD Research

    Objective/Rationale
    A biochemical biomarker is a chemical in bodily fluids (e.g. blood, cerebrospinal fluid, urine, etc.) that may be helpful in detecting Parkinson’s disease (PD) or in measuring the...

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