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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Rapid Response Innovation Awards, 2010
    Characterization of PARK16

    Objective/Rationale:
    Recently, a novel region of the genome containing genetic information predisposing to the development of Parkinson’s disease has been discovered through a collaborative study of...

  • Rapid Response Innovation Awards, 2010
    Deciphering the Molecular Effects of Alpha-Synuclein in the Nucleus: DNA Binding and Transcriptional Dysregulation

    Objective/Rationale:
    A-synuclein, the main component of Lewy bodies, is thought to be present mostly on nerve terminals. Although the function of a-synuclein is unclear, its presence in the nucleus of...

  • Rapid Response Innovation Awards, 2010
    Susceptibility Genes for Antipsychotic-induced Extrapyramidal Symptoms as Modifier Genes in Parkinson's Disease and L-dopa Treatment Response

    Objective/Rationale:
    The use of antipsychotic drugs, all of which block dopamine D2 receptors, to treat schizophrenia and other psychotic states is associated with the development of motor acute...

  • Rapid Response Innovation Awards, 2010
    The Role of LRRK2 in Wnt Signaling In Vivo

    Objective/Rationale
    We have preliminary evidence that LRRK2, which is a key protein in Parkinson’s disease (PD), may have a role in an important cellular process called Wnt signaling. Thus it is...

  • Therapeutics Development Initiative, 2010
    Development of an Adult Adherent Allogeneic Stem Cell Product for Treatment of Parkinson's Disease

    Objective/Rationale:
    Previously published data illustrates that MultiStem®, an adult stem cell product approved by the FDA for Phase I studies in humans, works through multiple mechanisms of benefit...

  • Rapid Response Innovation Awards, 2010
    Determine the Structure of Roco Family Proteins

    Objective/Rationale:
    Our aim is the biochemical and structural characterization of the Roco family of proteins. Structures of different Roco constructs will give important insights in the molecular...

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