The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Target Advancement Program, 2022Mining for Protein Aberrations in Parkinson’s Disease Using Large-Scale Protein Databases
Study Rationale: Deficient clearance of misfolded alpha-synuclein aggregates contributes to the pathology of Parkinson’s disease (PD). But broader disturbances in proteostasis—the balanced production...
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Target Advancement Program, 2022Assessing the Neuroprotective Factor REST/NRSF as a Therapeutic Target for Parkinson’s Disease
Study Rationale: Evidence suggests that a regulatory factor called REST (also known as NRSF) could promote the survival of neurons in neurodegenerative conditions. Studies have shown that this...
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Research Grant, 2022Developing a Strategy to Determine Why Melanoma and Parkinson's Disease Occur Together
Study Rationale: Having melanoma increases the risk for Parkinson's disease (PD)—and vice versa. The cellular basis for this association is not known. To identify the key cellular events that enhance...
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Expanding Biological Understanding of Parkinson's Disease, 2022Evaluating the Role of Miro1 in Mitochondrial Quality Control in Parkinson’s Disease
Study Rationale: Growing evidence suggests that dysfunction is linked to Parkinson’s disease (PD). These structures supply cells with energy, but must be eliminated when they become damaged — a...
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Research Grant, 2022Shoring Up a Medical Chemistry Approach to Treating Parkinson’s Disease: The Bridge Initiative
Study Rationale: The proteins parkin and GCase show a strong genetic link to Parkinson’s disease (PD) and are key players of biological pathways often disrupted in the disorder. This connection makes...
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Translational Pipeline Program, 2022Development of a Nurr1 Activator as a Novel Therapeutic for Parkinson’s Disease
Study Rationale: Nurr1 is a protein that works in the nucleus of dopamine-producing nerve cells in the brain to keep these cells functioning normally. Emerging evidence suggests that impaired function...
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Our funding programs support basic, translational and clinical research from academia and industry.