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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Research Grant, 2013
    Is ATP13A2 a Lysosomal Lipid Flippase that Affects Alpha-synuclein Membrane Interactions?

    Promising Outcomes of Original Grant:
    One of the objectives of the original study was the development of biochemical and cell-based assays for measuring ATP13A2 protein activity. We largely achieved...

  • Synuclein Therapeutic Acceleration Program, 2013
    Immunotherapy with Alpha-synuclein Specific Antibody

    Objective/Rationale:             
    The protein alpha-synuclein is believed to play a major role in the development of Parkinson’s disease (PD). Toxic forms of alpha-synuclein can cause neuronal...

  • Research Grant, 2013
    A New Pharmaceutical Target for Mono and Add-on Therapy in Parkinson’s Disease

    Objective/Rationale:             
    We are targeting a molecule, for the first time in Parkinson’s research, that is only present in the human brain’s motor circuitry and that we believe will respond to...

  • LRRK2 Challenge, 2013
    Direct Activity Sensor for Interrogating LRRK2 in Complex Biological Samples

    Objective/Rationale:
    Mutations in Leucine-Rich Repeat Kinase 2 (LRRK2) that increase the kinase’s activity – transferring groups of chemicals called phosphates – have been associated with...

  • Research Grant, 2013
    LRRK2 Phosphatases Confirmation

    Promising Outcomes of Original Grant:
    The molecular events that precipitate the onset of Parkinson’s disease (PD) have yet to be precisely defined; however current research indicates that the Leucine...

  • Dyskinesia Challenge, 2013
    Deciphering the Role of Histone Deacetylase in Levodopa-Induced Dyskinesia

    Objective/Rationale:
    It is well known that repeated administration of levodopa causes gradual changes in striatal gene expression that eventually result in the development of levodopa-induced...

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Our funding programs support basic, translational and clinical research from academia and industry.

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