The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2014Identification of Small Molecule Activators of Parkin Protein
Objective/Rationale:
Loss of parkin protein in humans leads to loss of dopamine neurons and ultimately Parkinson’s disease (PD). Loss of parkin activity is linked to young-onset familial PD, as well as... -
Research Grant Supplement, 2014PERK Signaling in Parkinson’s Disease Progression
Promising Outcomes of Original Grant:
The original study validated the role of PERK (protein kinase RNA-like endoplasmic reticulum kinase) signaling in the progression of Parkinson’s disease (PD). We... -
Rapid Response Innovation Awards, 2014Optogenetics-based, Photo-switchable Model of Parkinson’s Disease for Drug Screening
Objective/Rationale:
Neurodegeneration has proven notoriously difficult to study. The main barrier to progress has been the challenging, heterogeneous nature of brain tissue. Optogenetics is a... -
Research Grant Supplement, 2014GluN2D Antagonism in the Subthalamic Nucleus for the Treatment of Parkinsonism
Promising Outcomes of Original Grant:
The goal of the original grant was to identify new chemical compounds that block specific types of receptors for the neurotransmitter glutamate and test whether... -
Rapid Response Innovation Awards, 2014Motor Proteins as Novel Drug Targets of Disease-modifying Treatments for Parkinson’s Disease
Objective/Rationale:
More and more research suggests that part of the cellular quality control mechanism, which degrades abnormal proteins or damaged parts of the cell, is defective in Parkinson’s... -
Research Grant, 2014Probing Nurr1 Expression in Parkinson’s Disease
Objective/Rationale:
Impaired function of the hormone receptor Nurr1 might contribute to the pathogenesis of Parkinson’s disease (PD) and is an active target for novel therapeutics. Previous studies...
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Our funding programs support basic, translational and clinical research from academia and industry.