The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Improved Biomarkers and Clinical Outcome Measures, 2015Developing Progression Markers of Parkinson’s Disease with Multimodal Structural MRI of Substantia Nigra and Locus Coeruleus
Study Rationale:
Substantia nigra pars compacta (SNpc) and locus coeruleus (LC) are key brain areas involved in Parkinson’s disease. The loss of important chemicals (dopamine and norepinephrine) made... -
Research Grant Supplement, 2015Identification of the Parkin-binding Domain for SLP-2 as a Potential Therapeutic Target Supplement
Promising Outcomes of Original Grant:
The objective of our Rapid Response Innovation Awards-supported project was to identify the parkin domain that interacts with Stomatin-like protein 2 (SLP-2), a... -
Research Grant, 2015Nuclear Magnetic Resonance Analysis to Support Development of Alpha-Synuclein Imaging Agents
Study Rationale:
The Michael J. Fox Foundation Imaging Consortium has identified several promising compounds that bind specifically to alpha-synuclein fibrils, the clumps of protein that accumulate in... -
Target Validation, 2015Transcription Factors as Key Targets to Regulate The Selective Vulnerability of Dopamine Neurons
Study Rationale:
Why specific subsets of brain cells such as those containing the chemical messenger dopamine are particularly vulnerable and degenerate is one of the central... -
Research Grant, 2015CAPTURE-PD: Cutaneous Autonomic Pilomotor Testing to Unveil the Role of Neuropathy Progression in Early Parkinson’s Disease
Study Rationale:
Parkinson’s disease is a progressive neurodegenerative disorder that does not only affect movement but also the autonomic nervous system. Since most people start... -
Research Grant Supplement, 2015Hit-to-Lead Optimization of Parkin Activators through Structure-Function Analyses
Objective/Rationale:
This project aims to develop potent small molecule activators of Parkin, which is mutated in some forms of familial Parkinson’s disease and might also be inactivated...
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Our funding programs support basic, translational and clinical research from academia and industry.