The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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LRRK2, 2011LRRK2 Role on Auto-Antibody Production by Human B Cells
Objective/Rationale:
LRRK2 expression has been demonstrated in the brain and several organs, including the thymus and spleen, which are major immune system organs for B and T lymphocyte maturation... -
Rapid Response Innovation Awards, 2011Functional Characterization of ATP13A2, a P-type Transport ATPase Involved in Neurodegeneration
Objective/Rationale:
Mutations in the ATP13A2 gene lead to the Kufor-Rakeb syndrome, a severe early-onset form of Parkinson’s disease (PD) with dementia. The ATP13A2 protein is targeted to cellular... -
Resource: Utilizing DATATOP Biospecimens, 2011Using Human Cerebrospinal Fluid Samples Collected in DATATOP Study for Biomarker Validation in Patients with Parkinson disease
Objective/Rationale:
One of the major challenges in biomarker discovery/validation for Parkinson's disease (PD) is to define their utility in PD progression. This task is best tackled with the... -
Rapid Response Innovation Awards, 2011Unlimited Discovery of Non-Coding, Regulatory RNAs and Aberrant Splicing in Parkinson's
Objective/Rationale:
The recent discovery of a hidden universe of regulatory, non-coding transcripts and previously unknown variants of protein-coding transcripts is challenging conventional thinking... -
Biomarkers, 2011Development of an MRI-based Imaging Biomarker for the Detection of Alpha-Synuclein in Parkinson's disease
Objective/Rationale:
Parkinson’s disease is associated with accumulation of the protein α-synuclein in the brain, however, it is not currently possible to detect α-synuclein in the brain of Parkinson... -
Target Validation, 2011Preferential Targeting of Subpopulations of 5-HT1A Receptors
Objective/Rationale:
Although Parkinson's disease (PD) is primarily caused by dopamine dysfunction, function of serotonin (another neurotransmitter) is also affected. This suggests that serotonergic...
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