The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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MJFF Research Grant, 2011Screening & Identification of Small-molecule Pharmacophores Modulating LRRK2 Activity
Objective/Rationale:
Excessive activity of a human enzyme, named “LRRK2”, is closely associated with Parkinson’s Disease (PD). Small chemical compounds that inhibit this enzyme may be extremely... -
MJFF Research Grant, 2011Analysis of a Viral Non-coding RNA as a Novel Therapeutic in a Chronic MPTP Pre-clinical Model of Parkinson's Disease and its Mechanism of Mitochondrial Protection
Promising Outcomes of Original Grant:
Previously, we identified a viral RNA which could act as a novel protective agent in models of PD, when delivered before experimental damage to neurons of the... -
Biomarkers, 2011GSTpi as a Blood Based Biomarker for Parkinson's Disease
Objective/Rationale:
The goal of this research project is to develop and validate a blood test that would identify individuals at risk for developing Parkinson’s disease and at a point in time prior... -
MJFF Research Grant, 2011Multi-tracer positron emission tomography (PET) functional imaging as a tool to assess the relevance of rodent LRRK2 models to the human neurochemical phenotype associated with LRRK2 mutations related Parkinsonism
Promising Outcomes of Original Grant:
The goals of the original grant were to develop PET (a non invasive imaging technique used in the study of human Parkinson’s disease ) –derived measures of... -
LRRK2, 2011LRRK2 Role on Auto-Antibody Production by Human B Cells
Objective/Rationale:
LRRK2 expression has been demonstrated in the brain and several organs, including the thymus and spleen, which are major immune system organs for B and T lymphocyte maturation... -
Rapid Response Innovation Awards, 2011Functional Characterization of ATP13A2, a P-type Transport ATPase Involved in Neurodegeneration
Objective/Rationale:
Mutations in the ATP13A2 gene lead to the Kufor-Rakeb syndrome, a severe early-onset form of Parkinson’s disease (PD) with dementia. The ATP13A2 protein is targeted to cellular...
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Our funding programs support basic, translational and clinical research from academia and industry.