The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Target Validation, 2015Targeting the NLRP3 Inflammasome in Models of Parkinson's Disease
Objective/Rationale:
Chronic inflammation within the brain is emerging as a possible driver in the progression of Parkinson’s disease (PD). Inflammasomes are protein complexes that... -
Research Grant, 2015VPAC2 Agonists Neuroprotective and Anti-inflammatory Effects in Parkinson's Disease
Study Rationale:
The adaptive and innate immune responses play intricate roles in modulating neuroinflammation and may be harnessed for neuroprotection from Parkinson’s disease. We... -
Therapeutic Pipeline Program, 2015Improving Access to Depression Care in Parkinson’s Disease: A Telehealth Approach
Study Rationale:
There is a critical need for treatments that address depression and barriers to care among the approximately 5 million people living with Parkinson’s disease (PD)... -
Biomarker Development, 2015Comparison of Pre- and Post-mortem Cerebrospinal Fluid Levels of Proteins and Lipids
Study Rationale:
Alpha-synuclein aggregation in the brain is the main pathology of Parkinson’s disease (PD). Cerebrospinal fluid (CSF) levels of alpha-synuclein are lower in PD. It... -
Dyskinesia Challenge, 2015Biomarkers and Sensors for Levodopa-induced Dyskinesia
Study Rationale:
Levodopa is the gold-standard drug for treatment of Parkinson’s disease (PD), but chronic use is associated with serious motor complications called levodopa-induced... -
Dyskinesia Challenge, 2015Targeting M4 Muscarinic Receptors for the Treatment of Levodopa-induced Dyskinesia
Study Rationale:
Levodopa-induced dyskinesia is thought to stem from sustained stimulation of D1 dopamine receptors (D1Rs). One potential strategy for diminishing excessive D1R...
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Our funding programs support basic, translational and clinical research from academia and industry.