The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2015Pre-clinical Development of the Oligomer Modulator anle138b and Establishment of a Novel Seeding-based Biomarker
Promising Outcomes of Original Grant:
In our previous work, we assessed the therapeutic potential of the oligomer modulator anle138b in pre-clinical models of Parkinson’s disease (PD). Anle138b... -
Target Validation, 2015Enhancing Mitochondria Quality Control in Parkinson’s via Activation of the Caseinolytic Peptidase
Study Rationale:
Reinforcement of mechanisms that maintain the health of the cell’s energy generator, its mitochondria, may combat age-related diseases including Parkinson’s disease... -
Target Validation, 2015Modulation of Microglia Cannabinoid Receptor 2 to Treat Neuroinflammation in Parkinson’s Disease
Study Rationale:
Numerous studies have highlighted a potential role of neuroinflammation in Parkinson’s disease whereby the immune cells of the brain called microglia may produce... -
Therapeutic Pipeline Program, 2015Effects of Transcranial Stimulation on Freezing of Gait in Parkinson's Disease
Study Rationale:
Many people with Parkinson's disease experience freezing of gait, when the person is unable to move forward, despite his or her best efforts. Although it is not exactly clear why or... -
Access to Data and Biospecimens, 2015New Tools for Direct Visualization of Individual Oligomers in Human Biofluids
Objective/Rationale: We have developed a completely new optical technique called SOAP imaging (single oligomers of amlyoidigenic proteins). This can be used to directly visualize the protein clumps...
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Access to Data and Biospecimens, 2015BioFIND: Analysis of A-beta, Tau and P-tau in CSF Samples
Study Rationale: Mixed pathology is common in all neurodegenerative diseases including Parkinson’s disease (PD). Three cerebrospinal fluid (CSF) biomarkers, Ab1-42, t-tau and p-tau181, provide an...
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Our funding programs support basic, translational and clinical research from academia and industry.