The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Priority Biology, 2020Effects of LRRK2 Variants on GCase Activity in iPSC-derived Dopamine Neurons and Microglia
Study Rationale:
There is contradictory evidence on whether the LRRK2 and GBA genes, and the proteins that they encode, interact in their effects on Parkinson’s disease. Some studies suggest that... -
Research Grant, 2020Revisiting Alpha-synuclein Pathology Staging and Detection Using an Expanded Antibodies Toolset
Study Rationale:
The levels of alpha-synuclein aggregates and their spreading to different brain region seem to correlate with Parkinson’s disease (PD) progression and symptoms. Increasing evidence... -
Priority Biology, 2020Structural Insights into Activated Intermediates of Parkin Continued
Study Rationale:
Loss of proteins responsible for removing damaged mitochondria (the cell power plants) is the most common cause of young-onset Parkinson’s disease (YOPD). Parkin and PINK1 are key... -
Research Grant, 2020Molecular Basis of Neurodegeneration in GBA-associated Parkinson’s Disease
Study Rationale:
Studies in human genetics have implicated the malfunction of a cellular compartment called the lysosome in the pathogenesis of Parkinson’s and other brain diseases. Lysosomes are... -
Research Grant, 2021Genotyping of Lymphoblastoid Cell Lines from Familial and Sporadic Parkinson’s Disease
Study Rationale:
Our previous studies show deficits in a cell activity called centrosome cohesion in cells from people with Parkinson’s disease (PD) and a LRRK2 mutation. These deficits are reverted... -
Priority Biology, 2021LRRK2 Regulation of Melanoma Progression
Study Rationale:
People with Parkinson's disease (PD) are more likely to develop melanoma, and people with melanoma are more likely to develop PD than the general population. Additionally, melanoma...
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Our funding programs support basic, translational and clinical research from academia and industry.