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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Rapid Response Innovation Awards, 2011
    Use of HspB1 Chaperone to Inhibit Pathological Alpha-synuclein Aggregation

    Objective/Rationale:
    The misfolding and aggregation of the protein alpha-synuclein has been identified as pivotal event causing Parkinson's disease. All cells in our body possess so-called chaperones...

  • Target Validation, 2011
    Ghrelin Agonist as a Novel Therapeutic Approach to Alleviate Gut Dysmotility and Levodopa-inhibited Gastric Emptying in PD Models

    Objective/Rationale:

    Patients with Parkinson’s disease (PD) have altered progression of ingested aliments/liquid from their stomach to the intestine, as well as suffer from constipation, and there is...

  • LRRK2 Cohort Consortium, 2011
    Autonomic Profiles of LRRK2 Mutation Carriers with Parkinson’s Disease and Non-manifesting, First-degree Relatives

    Objective/Rationale:
    Autonomic disturbances are common symptoms of Parkinson’s disease (PD). We propose to analyze data on autonomic function collected from PD patients and relatives of PD patients...

  • Research Grant, 2011
    Pre-clinical Development of Encapsulated Cell Biodelivery of GDNF for Parkinson's Disease

    Objective/Rationale:
    Glial cell line-derived neurotrophic factor (GDNF) is a protein that can aid in survival of the dopamine cells that die in Parkinson’s disease (PD). Treatment with GDNF in PD has...

  • MJFF Research Grant, 2010
    Promoting Widespread Data Sharing Among Scientists

    Objective/Rationale
    When scientists carry out experiments and observations, they typically have very specific questions.  It is frequently the case that data collection is relevant to issues and...

  • Target Validation, 2010
    Pharmacodynamics and Neuroprotective Effects of Pegylated G-CSF

    Promising Outcomes of Original Grant:
    We have discovered that a specific protein, granulocyte-colony stimulating factor (G-CSF), is effective in reducing nerve cell death and thereby disease...

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