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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Access to Data & Biospecimens, 2017
    Klotho and Parkinson’s disease

    Study Rationale:                   

    Genetic studies have identified a powerful “aging suppressor gene”, Klotho, that may play a role in delaying age-related declines in cellular and tissue functioning...

  • Target Advancement Program, 2017
    Disruption of Pathological Protein-protein Interactions in Alpha-synuclein

    Study Rationale:
    The spread of alpha-synuclein (sticky protein that clumps in the brains of those with Parkinson's) occurs through a cell-to-cell prion-like (spreading) mechanism. Disrupting the...

  • Therapeutic Pipeline Program, 2017
    Cell-Permeable Parkin Protein Suppresses Parkinson's Disease-associated Symptoms

    Study Rationale:
    The Parkin protein (encoded by the PARK2 gene that is linked to Parkinson's), has been shown to exert potent neuroprotective effects that could potentially be used to treat Parkinson's...

  • Research Grant, 2017
    Promoting Mitochondrial Transport in Dopaminergic Neurons

    Study Rationale:
    Healthy mitochondria (powerhouses of the cell) are crucial to the survival of neurons, and poorly-functioning mitochondria are implicated in the neurodegeneration associated with...

  • Target Advancement Program, 2017
    Preventing Misfolded Alpha-synuclein Accumulation

    Study Rationale:
    The pathological hallmark of Parkinson's disease (PD) is the widespread accumulation of cellular deposits (Lewy Bodies) comprised of clumps of a misfolded protein called alpha...

  • Improved Biomarkers and Clinical Outcome Measures, 2017
    Regulation of the SNCA Gene in Parkinson's Disease

    Study Rationale:
    DNA methylation is a regulatory mechanism that can turn genes on or off within the cells in our body. In Parkinson's disease (PD), methylation near SNCA (a gene linked to PD) is lower...

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Our funding programs support basic, translational and clinical research from academia and industry.

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