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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Research Grant, 2017
    From Nose to Diagnostics: Development of an Accessible Screening Platform for Early Diagnosis of Parkinson's Disease

    Study Rationale:
    The aim of this study is to determine if chemicals found on the skin of those with Parkinson's disease (PD) can be used as a way to diagnose PD before motor symptoms develop. We have...

  • Research Grant, 2017
    Development of a Clinical Flow Cytometry Assay for Accurate and Selective Measurement of GBA1 Activity in Peripheral Blood Mononuclear Cells

    Study Rationale:
    A protein in the brain known as glucocerebrosidase may not work properly in those with Parkinson's disease (PD). Methods currently used to monitor the activity of this protein within...

  • LRRK2 Therapeutic and Safety Initiative, 2017
    The Effects of a LRRK2 Inhibitor on Alpha-synuclein-induced Dopamine Deficits in a Pre-clinical Model of Parkinson's Disease

    Study Rationale:
    In a previous study, we demonstrated that PFE360, an LRRK2 inhibitor, has neuroprotective benefits. However, several questions remain unanswered as follows: (1) Did the vehicle...

  • Research Grant, 2017
    Development of PET Tracers for Synucleinopathies

    Promising Outcomes of Original Grant:
    Our project aims to develop a brain imaging agent for alpha-synuclein, a key protein involved in Parkinson’s disease (PD) pathology. Such an agent will help (i)...

  • Research Grant, 2017
    Microbiome Biomarkers for Early-stage Detection and Stratification of Parkinson's Disease

    Study Rationale:
    Parkinson's disease (PD) research benefits from knowledge of disease-specific risk and resilience factors and elucidation of pathophysiological concepts on the emergence of...

  • Research Grant, 2017
    Study of a Molecule to Prevent Alpha-Synuclein Clumping and Treat Parkinson's Disease

    Promising Outcomes of Original Grant:
    Alpha-synuclein is a sticky protein that clumps in the brains of people with Parkinson's disease (PD). In our first project funded by The Michael J. Fox Foundation...

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Our funding programs support basic, translational and clinical research from academia and industry.

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