The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Parkinson’s Disease Therapeutics Pipeline Program, 2024A Novel Brain-penetrating Antibody for Treating Parkinson’s Disease
Study Rationale: Inflammation in the brain is an important trigger of Parkinson’s disease (PD). Our strategy is to block one of the key molecules mediating inflammation and degeneration in the brain...
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Parkinson’s Disease Therapeutics Pipeline Program, 2024IND-enabling Studies of a Molecule that Enhances Mitophagy as Disease-modifying Therapy for Parkinson's Disease
Study Rationale: Studies show that Parkinson's disease (PD) is frequently associated with damage to mitochondria, structures that provide cells with the energy they need to function. In particular, a...
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Parkinson’s Disease Therapeutics Pipeline Program, 2024Targeting LRRK2 Dysfunction Using Aptamers in People with Parkinson’s Disease
Study Rationale: Activating mutations in LRRK2 are a common cause of Parkinson’s disease (PD). We propose using aptamers to inhibit LRRK2. Aptamers are snippets of DNA or RNA that can fold into shape...
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Parkinson’s Disease Therapeutics Pipeline Program, 2024Biomarker Development and IND-Enabling Toxicology Support for Novel, Small Molecules that Enhance Lysosomal Function for the Treatment of Parkinson’s Disease
Study Rationale: In people with Parkinson’s disease (PD), neurons exhibit decreased ability to remove cellular trash. This dysfunction is caused by a reduction in the number and effectiveness of the...
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Research Grant, 2024(SUPPLEMENT) Disparities in Neurocognitive Impairment among Hispanics/Latinos in the US with Parkinson’s Disease: The Role of Cardiovascular Risk
Study Rationale: In the United States, Latinos with Parkinson’s disease (PD) are more likely to have problems with memory, planning and other thinking skills than people with PD of other ethnic/racial...
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Research Grant, 2024Validation of Functional Staging of Parkinson’s Disease Using the Critical Path for Parkinson’s (CPP) Integrated Parkinson’s Database
Study Rationale: Researchers recently proposed defining Parkinson’s disease (PD) based on a test for abnormal alpha-synuclein in spinal fluid and adopting a staging system based on measures (or scales...
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Our funding programs support basic, translational and clinical research from academia and industry.