The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Target Advancement Program, 2016Mechanism of TFEB Dysfunction by GBA1 Mutation in Human iPSC-derived Dopaminergic Neurons
Study Rationale:
People who have mutations in the GBA1 gene have a higher chance of developing Parkinson's disease (PD) but it is unclear why. We found that GBA1 mutations affect the cellular ability... -
PPMI Data Challenge, 2016Subtyping Parkinson’s Disease with Deep Learning Models (2016 PPMI Data Challenge Winner)
Study Rationale:
As Parkinson's disease (PD) is highly heterogeneous, identifying coherent PD subtypes is crucial for understanding the underlying mechanism of the disease and designing and testing... -
PPMI Data Challenge, 2016Multivariate Prediction of Parkinson's Disease Clinical Progression (2016 PPMI Data Challenge Winner)
Study Rationale:
Parkinson's disease (PD) is heterogeneous in both clinical representation and prognosis, as indicated by a large diversity of rates of progression in motor as well as non-motor... -
Target Advancement Program, 2016Farnesoid X Receptor as a Target to Reduce Meuroinflammation
Study Rationale:
Although the precise mechanism(s) of neurodegeneration in Parkinson's disease (PD) are unknown, evidence suggests that neuroinflammation is an important contributor. In this study, we... -
Research Grant, 2016The Determinants and Functional Consequences of LRRK2 Dimer Formation
Study Rationale:
The protein LRRK2 has a strong tendency to self-associate in pairs, which plays an important role in how it functions in cells. Mutations in LRRK2 that cause a type of Parkinson's...
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Target Advancement Program, 2016Neuroprotective Effects of Endosulfine-alpha in PD
Study Rationale:
Evidence suggests that alpha-synuclein can cause cell death in the brains of those with Parkinson's disease (PD) by forming clusters (or aggregates) on the surface of small storage...
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Our funding programs support basic, translational and clinical research from academia and industry.