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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Target Advancement Program, 2016
    Investigating the Effect of Parkin on Alpha-synuclein Propagation

    Study Rationale:
    Parkinson's disease (PD) has been demonstrated to start within the olfactory bulb (brain region that processes smell) and brain stem (brain region that controls involuntary functions)...

  • Target Advancement Program, 2016
    Structural Insights into Activated Intermediates of Parkin

    Study Rationale:
    Failure in the quality control of mitochondria (power houses of the cell) in neurons may contribute to Parkinson's disease (PD). Parkin is an enzyme that tags proteins from damaged...

  • Research Grant, 2016
    Identification of Slow Off-rate Modified Aptamer Reagents that Specifically Bind Phosphorylated LRRK2

    Study Rationale:
    Mutations in the LRRK2 gene are the leading cause of familial Parkinson's disease (PD), often resulting in increased kinase activity and phosphorylation (modification) of several...

  • Research Grant, 2016
    Convergence of LRRK2 and GBA1 in the Pathogenesis of Parkinson's Disease

    Study Rationale:
    Genetic studies in Parkinson's disease (PD) have led to the discovery of several causal and risk genes, whose mutations contribute to some forms of PD; among those described are...

  • Target Advancement Program, 2016
    Investigation of Lipid Metabolism in GBA-associated Parkinsonism

    Study Rationale:
    Genetic changes in the glucocerebrosidase (GBA) gene are linked to a higher risk of developing Parkinson's disease (PD) and dementia with Lewy bodies (DLB). These changes in GBA in...

  • Improved Biomarkers and Clinical Outcome Measures, 2016
    Corneal Confocal Microscopy: A Novel Imaging Biomarker for Parkinson's Disease

    Study Rationale:
    We have pioneered a technique in which we can photograph nerves on the surface of the eye. This technique can be used to monitor the severity of various neurological conditions. In our...

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